The National Drug Early Warning System (NDEWS) Naloxone Phase II Replication Studies were designed to explore the feasibility of rapidly addressing timely research questions by adding questions to ongoing studies already in the field. Information about the awareness and availability of naloxone, attitudes towards naloxone, and naloxone’s influence on drug use was collected from a local (Baltimore, MD) and a national (Researched Abuse, Diversion and Addiction-Related Surveillance [RADARS®] System) sample of persons seeking treatment for opioid use disorder (OUD). A smaller, Phase I study formed the basis for the Phase II replication studies.

Highlights from the Naloxone Phase II Studies


Second round studies:

Characterizing Knowledge, Attitudes, Behaviors, and Practices Related to Bystander Naloxone in Methadone-Maintained Individuals with Opioid Use Disorder

Annabelle M. Belcher, PhD, Thomas O. Cole, MA, Mark Yoon, MA, Alexander Pappas, MD, Zofia Kozak, MD, Christopher Welsh, MD, Eleanor Erin Artigiani, MA, Eric D. Wish, PhD


A Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS®) System Report: RADARS® System Treatment Center Programs Combined Study of Naloxone Experiences and Attitudes

Stevan Geoffrey Severtson, Marie Gurrola, David Grundy, Heather Olsen, Janetta Iwanicki



First round studies:

Nobody Wants to Be Narcan’d: A Pilot Qualitative Analysis of Drug Users’ Perspectives on Naloxone


Quick turnaround substudies on naloxone in three cities (2019): Cleveland, Ohio; Worcester, Massachusetts; Baltimore, Maryland.

Cleveland, Ohio

Lee Hoffer, Ph.D., MPE, Allison Schlosser, Ph.D., MSW, and Kayla Buckelew


Download report

Worcester, Massachusetts

Jeffrey T. Lai, MD, Charlotte Goldfine, MD, Brittany P. Chapman, BSc, Melissa M. Taylor, BA, Rochelle K. Rosen, Ph.D., Stephanie P. Carreiro, MD, and Kavita M. Babu, MD

Download report

Baltimore, Maryland

Annabelle M. Belcher, Ph.D., Thomas O. Cole, MA, Alexander Pappas, MD, Raman Sandhu, MD, Rachel Steere, DO, and Zofia Kozak, BS

Download report

Last modified
08/13/2021 - 11:30 am